| Wednesday 24 September |
| 08:30 - 13:30 |
Junior Faculty Grant Writing Workshop
This workshop is intended to provide in depth and personalized mentoring in grantsmanship for junior faculty members and senior post-doc members of the ISEH.
Learn More |
| 09:00 - 12:00 |
China-Japan Joint Workshop on Stem Cells and Cell Therapy
Join us for this free symposium featuring world leading scientists from China and Japan presenting research and the latest developments in stem cells and cell therapy.
View the Workshop Schedule |
| 13:00 - 18:00 |
New Investigators Pre-Meeting Workshop*
Join us for a pre-meeting workshop designed for PhD students and postdoctoral fellows with a focus on collaboration.
View the Workshop Schedule
iPSC-derived Hematopoiesis Symposium**
Learn More
*Ticketed event, additional purchase required.
**This is an event planned by Eirini Papapetrou, Christopher Sturgeon, Sergei Doulatov, Shin Kaneko.
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| 19:00 - 21:00 |
Junior Faculty Networking Workshop***
Join the ISEH Junior Faculty Committee for an educational and networking workshop with fellow new faculty members.
*****Ticketed event. Additional purchase required.
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| Thursday 25 September |
| 08:00 - 18:30 |
Registration Open |
| 08:45 - 10:30 |
Scientific Session 1: Donald Metcalf Award Lecture followed by Red Cells and Platelets
2025 Awardee: Constanze Bonifer, PhD, Murdoch Children’s Research Institute, Australia
How cell stage-specific transcription factors and outside signals regulate hematopoietic stem cell development and differentiation – a journey through time (1001)
Invited Speakers
Hozumi Mothohashi, MD, PhD, Tohoku University, Japan
Mitochondria Regulate the Cell Fate Decisions of Megakaryocyte-Erythroid Progenitors (1002)
Sherry Hsiang-Ying Lee, PhD, Peking University, China
Disrupted Erythroid–Immune Interactions in Acquired PRCA: Mechanisms and Clinical Implications (1003)
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| 10:30 - 11:00 |
Break + Exhibitor Hours |
| 11:00 - 12:20 |
Scientific Session 2: Presidential Symposium
Chair: Shannon McKinney-Freeman, PhD
John Tisdale, MD, National Institutes of Health, USA
TBA (1004)
Hanna Mikkola, MD, PhD, University of California Los Angeles, USA
TBA (100)
EMBO Keynote Lecture: Sean Morrison, PhD, UT Southwestern Medical Center, USA
Hematopoietic stem cell activation for blood regeneration (1006)
Featured Posters
Jakushin Nakahara, MSc, University of Tokyo, Japan
PCYT1A is a metabolic vulnerability in monocytic acute myeloid leukemia (3001)
Mingming Niu, Institute of Hematology & Blood Diseases Hospital, China
Integration of CRISPR-Cas9 Screens and Multi-Omics Profiling Reveals CHD7-ANGPT1 as a Novel Multidrug Resistance Axis in AML (3002)(Late-breaking abstract)
Maria Jassinskaja, PhD, Lund University, Sweden
Mass Spectrometry-Based Profiling of Bone Marrow Niche Secretome Remodeling in Aging and Tet2-mutant Clonal Hematopoiesis (3003)
Qinyu Zhang, PhD, Lund University, Sweden
In Vitro Expanded Hematopoietic Stem Cells Combined with Non-Genotoxic Conditioning Enable Efficient Transplantation and Suppress Myeloid Disease (3004)
|
| 12:40 - 14:20 |
Lunch + Exhibitor Hours |
| 12:30 - 13:15 |
Sponsored Lunch Symposia
Otsuka Pharmaceutical |
| 13:15 - 14:05 |
New Investigators Career Session
Junior Faculty Career Session |
| 14:15 - 15:45 |
Scientific Session 3: Paul S. Frenette Lecture
Invited Speakers
Lachelle Weeks, MD, PhD,Dana-Farber Cancer Institute
TBA (1007)
Short Talks
Dawn Lin, PhD, HI-STEM, Germany
EPCR expression marks super-dormant lymphoid-primed CD150neg hematopoietic stem cell (2001)
Grant Rowe, MD, PhD, Boston Children's Hospital, USA
Expedited monocyte-independent macrophage differentiation from a developmentally restricted human definitive hematopoietic stem cell (2002)
Lee Grimes, PhD, Cincinnati Children's Hospital, USA
Molecular dissection of aging clarifies the impact of MDS genetics and therapy (2003)
Featured Posters
Mari Carmer Romero-Mulero, PhD, ETH Zurich, Switzerland
Differentiation, aging and leukemia alters the metabolic profile of human bone marrow hematopoietic stem and progenitor cells (3005)
Marta Mastrogiovanni, PhD, Albert Einstein College of Medicine, USA
Embryogenic TGF- β signaling shifts myeloid cell clonality and functions (3006)
Anastasia Nizhnik, Albert Einstein College of Medicine, USA
HSPCs differentiate to a diverse set of lymphoid lineage immune cells during development (3007) (Late-breaking abstract)
Denise Ragusa, PhD, Brunel University of London, College of Health, Medicine and Life Sciences, Division of Biosciences, UK
Integrated in silico and in vitro approaches match developmental cell-of-origin to therapeutic vulnerabilities in infant leukemia (3008) (Late-breaking abstract)
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| 15:45 - 16:15 |
Break + Exhibitor Hours |
| 16:15 - 18:00 |
Scientific Session 4: Joint ISEH/JSH Symposium on Stress Hematopoiesis
Invited Speakers
Toshio Suda, MD, PhD, Institute of Hematology, Chinese Academy of Medical Sciences, China
Self-Renewal Activity of Hematopoietic Stem Cells from Birth to Aged (1008)
Hitoshi Takizawa, PhD, Kumamoto University, Japan
Tissue-specific inflammatory cue to drive early hematopoiesis (1009)
Short Talks
Julia Phan, PhD, UT Southwestern, USA
Retrotransposons are Co-Opted to Activate Hematopoietic Stem Cells and Erythropoiesis During Hematopoietic Stress (2004)
Tiago Luis, PhD, Imperial College London, UK
Regulation of hematopoietic stem cells quiescence and proliferation by the bone marrow niche during regeneration (2005)
Junya Sango, PhD, Icahn School of Medicine at Mount Sinai, USA
RAS mutations transform granulocyte-monocyte progenitors into inflammatory leukemia stem cells in acute myeloid leukemia (2006)
Featured Posters
Bart Weijts, PhD, Hubrecht Institute, Netherlands
Blood-resident macrophages (bMΦ) safeguard blood and vessel integrity (3009)
Shu wen Zheng, Zhejiang University, China
Small-molecule RPB1 degraders eradicate acute myeloid leukemia (3010)
Haruki Shirozu, MSc, IRCMS, Kumamoto University, Japan
Uncovering the mechanism of erythroid enucleation using non-mammalian models (3011)
Alexander Maytum, PhD, Murdoch Children's Research Institute, Australia
Vascular endothelial growth factor signalling blocks the development of human hematopoietic stem cells from induced pluripotent stem cells (3012)
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| 18:00 - 20:00 |
Welcome Reception + Posters with Authors (Odd Numbered Posters) |
| Friday 26 September |
| 08:00 - 19:00 |
Registration Open |
| 08:30 - 9:30 |
Meet the Experts Breakfast Mixer
*Ticketed event, additional purchase required. |
| 09:30 - 10:55 |
Scientific Session 5A (concurrent): Lymphoid Malignancies
Invited Speakers
Mamiko Sakata-Yanagimoto, MD, PhD,University of Tsukuba, Japan
Immune cells derived from clonal hematopoiesis form microenvironmental niches in malignant lymphomas (1010)
Edwin Hawkins, PhD,Walter and Eliza Hall Institute, Australia
TBA (1011)
Short Talks
Michael Rieger, PhD,Goethe University Frankfurt, Germany
Tracing clonal distribution and differentiation trajectories in B cell acute lymphoblastic leukemia using single cell barcoding (2007)
Katrin Ottersbach, PhD, University of Edinburgh, UK
Identification of novel CNS niche-specific immune regulation and growth factor signalling in infant KMT2A-rearranged B-ALL (2008)
Scientific Session 5B (concurrent): Innate Immune Cells
Invited Speakers
EMBO YIP Lecture: Elvira Mass, PhD, University of Bonn, LIMES Institute, Germany
Developmental Programming of Tissue-Resident Macrophages (1012)
Claudia Waskow, PhD, Leibniz Institute on Aging, Germany
TBA (1013)
Short Talks
Zining Yang, Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, China
Mast Cells Support Hematopoietic Stem Cell Function During the Transition to Bone Marrow Hematopoiesis (2009)
Momoko Yoshimoto, MD, PhD, WMU Homer Stryker MD School of Medicine, USA
Fetal-derived B-1 cells prevent CHIP-associate atherosclerosis (2010)
|
| 10:55 - 11:25 |
Break + Exhibitor Hours |
| 11:25 - 12:50 |
Scientific Session 6A (concurrent): Developmental Hematopoiesis
Owen Tamplin, PhD, University of Wisconsin-Madison, USA
Niche contact during development programs hematopoietic stem cells (1014)
Lili Jing, PhD, Shanghai Jiao Tong University, China
AHR regulates myeloid cell development and differentiation via CNR2 and enhances ATRA-induced differentiation and promotes cytotoxic response in leukemia cells (1015)
Short Talks
Norika Liu, PhD, Kumamoto University, Japan
The Embryonic Heart as a Transient Hematopoietic Site for Macrophage-Mediated Cardiac Remodeling (2011)
Youqi Wang, PhD, Hong Kong University of Science and Technology, Hong Kong
Dendritic cells in developing and adult zebrafish arise from different origins and display distinct flt3 dependencies (2012) (Late-breaking abstract)
Scientific Session 6B (concurrent): Myeloid Malignancies
Invited Speakers
Shannon Elf, PhD, University of Utah, USA
TBA (1016)
Tao Cheng, MD, Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, China
Dissecting the blood ecosystem in acute myeloid leukemia (1017)
Short Talks
Jean-Emmanuel Sarry, PhD, Cancer Research of Toulouse, France
An ecological community of distinct leukemic stem cell populations drives relapses in acute myeloid leukemia (2013)
Sepideh Azizi Taramsary, Adelaide University, Australia
TGFβ1 Regulates Leukemia Stem Cell Marker CD123 and Induces Chemotherapy Resistance (2014)
|
| 12:50 - 14:20 |
Lunch + Exhibitor Hours |
| 13:00 - 13:45 |
Experimental Hematology Editorial Board Meeting |
| 13:00 - 13:45 |
Sponsored Lunch Symposia |
| 14:20 - 15:45 |
Scientific Session 7A (concurrent): Lymphoid Biology
Invited Speakers
Joan Yuan, PhD,Lund University, Sweden
TBA (1018)
Jarrod Dudakov, PhD, Fred Hutchinson Center, USA
Dying to regenerate: Endogenous mechanisms of tissue repair in the thymus (1019)
Short Talks
Lev Kats, PhD,Peter MacCallum Cancer Centre, Australia
Menin orchestrates expression of the master plasma cell transcription factor IRF4 and is an actionable target in multiple myeloma (2015)
Shi Hao Tan, PhD, Cancer Science Institute of Singapore, Singapore
Targeting of mSWI/SNF Complex and UTX Reveals a Novel Combination Therapy in T-Cell Acute Lymphoblastic Leukemia (2016)
Scientific Session 7B (concurrent): Epigenetic Regulation of Normal and Malignant Hematopoiesis
Invited Speakers
Marta Derecka, PhD, St. Jude Children's Research Hospital, USA
Targeting the EBF1-ITGB8 Axis in the Bone Marrow Niche as a Promising Therapeutic Approach for Myelofibrosis (1020)
Atsushi Iwama, MD, PhD, The Institute of Medical Science, The University of Tokyo, Japan
Dysregulated Polycomb Repressive Complex 2 underlies the development of myeloid leukemia associated with Down syndrome (1021)
Short Talks
Alexandra Preston, PhD, University of Oxford, UK
Ancient genomic linkage of Nprl3 and α-globin couples metabolism with erythroid development (2017)
Yapu Li, PhD, Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, China
The RNA binding protein hnRNPF deficiency drives malignant transformation (2018)
|
| 16:45 - 16:15 |
Break + Exhibitor Hours |
| 16:15 - 17:55 |
Scientific Session 8: Janet Rowley Award Lecture followed by Stem and Progenitor Biology
2025 Awardee: Adam Wilkinson, University of Cambridge Department of Haematology and Cambridge Stem Cell Institute, UK
Haematopoietic stem cell expansion ex vivo (1022)
Invited Speakers
Camilla Forsberg, PhD,University of California Santa Cruz, USA
Blood for life: hematopoietic stem cells from womb to tomb (1023)
Satoshi Yamazaki, PhD, The Institute of Medical Science, The University of Tokyo, Japan
A Genetic Labeling Strategy for Competitive Xenotransplantation of Human HSCs (1024)
|
| 18:00 - 20:00 |
Posters with Authors (Even Numbered Posters ) |
| Saturday 27 September |
| 08:00 - 19:00 |
Registration Open |
| 08:45 - 10:35 |
Scientific Session 9: New Investigator Award Lecture
2025 NIC Invited Speaker: Shalin Naik, Walter and Eliza Hall Institute of Medical Research, Australia
TBA (1025)
Short Talks
Arianna Smith, BS, University of Florida, USA
Endothelial Cell-derived Thrombospondin-1 Negatively Affects Hematopoietic Function During Aging (2019)
Chang Xu, PhD, Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, China
Procr+Endothelial Progenitor Cells Orchestrate Hematopoietic Stem Cell Function via Mesenchymal Stem Cell-Mediated Regulatory Crosstalk (2020)
Cih-Li (Amy) Hong, DVM, MS, University of Rochester Medical Center, USA
Local Bone Remodeling Shapes Hematopoietic Stem Cell (HSC)- Macrophage Interactions and Compartmentalized HSC Expansion under Inflammatory Stress (2021)
Ashley Kamimar-Lanning, PhD, MRC Weatherall Institute of Molecular Medicine, University of Oxford, UK
Endogenous formaldehyde-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis (2022)
Tsuyoshi Fukushima, PhD, Institute of Medical Science University of Tokyo, Japan
Haematopoietic stem cells undergo bidirectional fate transitions in vivo (2023)
Marija Zarocsinceva, PhD, University of Cambridge, UK
A Step-wise and Deterministic Leukaemia Mouse Model Reminiscent of JMML with Endogenous Acquisition of Patient-relevant RTK–RAS Mutations (2024)
|
| 10:35 - 11:05 |
Break |
| 11:05 - 12:15 |
Scientific Session 10: ISEH-EHA Joint Session
Florian Perner, MD,Hannover Medical School, Germany
Cellular plasticity drives persistence and resistance of leukemia cells under menin inhibitor treatment (1026)
Zuzana Tothova, MD, PhD, Dana-Farber Cancer Institute, USA
TBA (1027)
Short Talks
Shinya Fujita, MD, PhD, National Institute of Global Health and Medicine, Japan Institute for Health Security, Japan
Piezo1 mechanosensing is a druggable target for hematopoietic stem cell homing to bone marrow (2025)
|
| 12:15 - 14:15 |
Lunch Break |
| 12:30 - 13:15 |
Sponsored Lunch Symposia |
| 13:15 -14:05 |
New Investigators Technology Session |
| 14:05 - 15:35 |
Scientific Session 11: Clonal Hematopoiesis and Aging
Invited Speakers
Jennifer Trowbridge, PhD, The Jackson Laboratory, USA
Mesenchymal Stromal Cell Senescence Augments Hematopoietic Cell Fitness in Clonal Hematopoiesis (1028)
Toshio Kitamura, MD, PhD, The University of Tokyo, Japan
TBA (1029)
Short Talks
Isabel Beerman, PhD, National Institute on Aging, USA
Age-associated chromatin reorganization drives overexpression of a novel Btaf1 variant regulating HSC self-renewal and MkP differentiation (2026)
|
| 15:13 - 15:35 |
ISEH Business Meeting and New Investigator Awards Announcement |
| 15:35 - 16:05 |
Break |
| 16:05 - 18:00 |
Scientific Session 12: Hematopoietic Microenvironment followed by McCulloch and Till Award Lecture
Short Talks
Pre-Meeting Workshop Winner
TBA (2027)
Invited Speakers
Keiyo Takubo, MD, PhD, Tohoku University, National Center for Global Health and Medicine, Japan
Identification of an endogenous expander for hematopoietic stem cells (1030)
Jason Butler, PhD, University of Florida, USA
Netrin-1 regulates hematopoietic stem cell function via UNC5A (1031)
2025 Awardee: Ulrich Steidl, Albert Einstein College of Medicine – Montefiore Medical Center, USA
Understanding and Targeting Stem Cell Heterogeneity in Normal and Malignant Hematopoiesis (1032)
|
| 18:00 - 18:05 |
Closing remarks |
| 19:00 - 22:00 |
Social Event*
*NOTE: Pre-registration and a ticket is required. If you registered with the plus package, a ticket to the social event is included.
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